Nitrergic modulation of cholinergic responses in the opossum lower oesophageal sphincter
نویسندگان
چکیده
منابع مشابه
Cholinergic blockade inhibits gastro-oesophageal reflux and transient lower oesophageal sphincter relaxation through a central mechanism.
BACKGROUND Atropine, an anticholinergic agent with central and peripheral actions, reduces gastro-oesophageal reflux (GOR) in normal subjects and patients with gastro-oesophageal reflux disease (GORD) by inhibiting the frequency of transient lower oesophageal sphincter relaxation (TLOSR). AIMS To compare the effect of methscopolamine bromide (MSB), a peripherally acting anticholinergic agent,...
متن کاملMeasurement of Lower Oesophageal Sphincter Pressure
In 24 control patients the lower oesophageal sphincter responded to graded increments in intra-abdominal pressure by a significant and sustained rise in tone. This response was abolished by atropine and was also absent in nine of 11 patients who had previously undergone truncal vagotomy for duodenal ulcer but not in the remaining two who had recurrent ulceration. In six patients studied after p...
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abnormal coagulation results, confirmed the diagnosis of disseminated intravascular coagulation. The transfusion of freeze-dried plasma (which has little if any coagulant activity), fibrinogen concentrate, and whole blood that she was given before admission would have had no appreciable effect on the coagulation results obtained and would not have caused the appearance of FDPs or fragmented red...
متن کاملMaturation of the lower oesophageal sphincter in the preterm baby.
There are few reported studies of the lower oesophageal sphincter in preterm infants and none has investigated babies of less than 34 weeks gestation. Using a modified manometric technique suitable for use on very low birth weight infants we have measured sphincter pressures on 68 occasions in 25 infants of postconceptional age between 27 and 41 weeks. In even the most preterm infants the lower...
متن کاملOesophageal acidification does not increase lower oesophageal sphincter pressure.
We studied the effect of distal oesophageal acidification on lower oesophageal sphincter (LOS) pressure in normal human volunteers and in cats. The distal oesophagus was acidified by intraluminal injection of 0.1N HCl (pH 1.2). The LOS pressure was recorded by a sleeve device while pharyngeal and oesophageal pressures were monitored by nonperfused, water filled catheters. In normal human subjec...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology
سال: 1997
ISSN: 0007-1188
DOI: 10.1038/sj.bjp.0701497